Journal article
HIV, Immune Dysfunction, and the Natural History of Anal High-Risk Human Papillomavirus Infection in Gay and Bisexual Men
IM Poynten, F Jin, SM Garland, RJ Hillman, M Molano, JM Roberts, DJ Templeton, S Phillips, C Law, CK Fairley, A Farnsworth, AE Grulich
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021
Abstract
Background: Incidence of anal cancer is highest in gay and bisexual men (GBM). Better understanding of the natural history of anal high-risk human papillomavirus (hrHPV) infection is needed for anal cancer prevention. Methods: The Study of the Prevention of Anal Cancer was a 3-year study of Australian GBM, aged 35 years or older. We examined incidence, clearance, and risk factors for 13 hrHPV types at baseline and 3 annual visits. Results: In 525 men with ≥ 2 visits, 348 (66.3%) acquired ≥ 1 incident hrHPV infection. HPV16 incidence rates were similar, but non-16 hrHPV incidence was higher in HIV-positive (51.8/100 person years [PY]) than HIV-negative men (36.5/100 PY, P?<.001). Annual clear..
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Awarded by National Health and Medical Research Council Program
Awarded by Cancer Council New South Wales Strategic Research Partnership Program
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council Program (grant number 568971 Sexually Transmitted Infections: Causes, Consequences and Interventions); and the Cancer Council New South Wales Strategic Research Partnership Program (grant number 1311 Preventing Morbidity and Mortality From Anal Cancer). Cytological testing materials were provided by Hologic (Australia) Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales and funded by the Australian Government Department of Health and Ageing.